Beilstein J. Org. Chem.2016,12, 2364–2371, doi:10.3762/bjoc.12.230
millimolar scale, they are easily scalable.
Keywords: green chemistry; nucleophilic substitution; planetary ball mill; siRNAdeliveryintermediate; sugammadex; Introduction
Cyclodextrins (CDs) are cyclic α(1→4)glucopyranosides and have been fully described in a number of publications [1][2][3]. They are
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Graphical Abstract
Scheme 1:
Synthesis of per-6-derivatized CDs. Ball milling conditions: 1500 steel balls of 1 mm diameter and ...